On 11/16/2009, Total Nutraceutical Solutions announced that they will be unable to file their next 10-Q by the deadline required by the SEC.

Total Nutraceutical Solutions announced that the company has started evaluating several proprietary mushroom compounds for activity in controlling the development of Alzheimer's Disease (AD). TNS was informed by Model Biosystems Inc. (MBS), San Clemente, CA, that a recent experiment in Drosophila melanogaster flies (Drosophila) showed that certain TNS proprietary mushrooms had unusual anti-inflammatory activity. MBS was of the opinion that TNS should evaluate these mushroom samples in a special MBS biologic model for Alzheimer's disease (AD). This proprietary AD model uses a genetic mutant of Drosophila that was developed in the laboratory of University of Texas, Galveston, Texas. This unique live model system can evaluate the activity of a given compound/ingredient in controlling biologic reactions and compounds that are associated with the development of human AD. The organic whole food mushrooms developed by TNS are being studied, pursuant to a signed research agreement, dated October 30, 2009, in a double-blinded investigator protocol; the total study will involve over 1,000 Drosophila with 120 organisms in each test group. Drosophila melanogaster, or fruit-fly is widely used in scientific and medical research.

Total Nutraceutical Solutions announced that the company has formulated and will launch a unique natural whole food mushroom-based Vitamin D supplement. This supplement is plant-based and not animal-based and provides a new approach to Vitamin D supplementation in health-conscious individuals. A proprietary grown mushroom, Agaricus blazei Murill (AbM) by Sylvan Bio Inc. and Creekside Mushrooms Limited will be stimulated with UV light to produce natural organic Vitamin D2 within the mushroom. The need for this product is underscored by the following statement in the October 26, 2009 issue of the Archives of Internal Medicine: 'The worldwide prevalence of Vitamin D deficiency is striking and more than 40% of the population may be Vitamin D deficient.' The importance of the timing of this product launch and the need for a natural whole food form of Vitamin D is further evidenced by a recent statement by the Office of Dietary Supplements, National Institutes of Health, that the second-best source of Vitamin D is 3 ounces of mushrooms enriched with Vitamin D. Many medical organizations, including the American Academy of Pediatricians, have advocated increased intake of Vitamin D, especially in children. Children's Hospital Boston reports that 62% of children taking multivitamins had below normal levels of vitamin D. The company has developed technologic capability that will allow production of a daily oral encapsulated natural supplement that contains enough Vitamin D equal to or greater than ten 8-ounce servings of Vitamin D fortified milk, at a cost that is affordable by most people.